VAEBAC Tutorial

Learn how to use the VAEBAC server for protein aggregation prediction.

Step 1 — Prepare Your Sequence

VAEBAC accepts protein sequences in FASTA format. You can paste the sequence directly or upload a FASTA file.

Example FASTA Sequence:

>Example_Protein
MTEITAAMVKELRESTGAGMMDCKNALSETQHEYLRTLHGRVYLHIGRDVGRAL

Step 2 — Submit to VAEBAC

Paste your sequence into the input box or upload a FASTA file, then click "Run Prediction".

Step 3 — Processing

The server will process your request automatically. Processing time depends on sequence length.

Step 4 — Results

After processing, VAEBAC provides:

Prediction probability for each protein
Classification: Amyloidogenic / Non-Amyloidogenic
Physicochemical feature summary
Visualization plots

Understanding the Output

Predictions are based on a probability threshold optimized during model validation. Proteins above this threshold are classified as Amyloidogenic.